The westbound A41 will be closed overnight between Berkhamsted and Tring for six weeks from next Wednesday while it is resurfaced.
During that period, between 8pm and 5am it will be open only to people with no alternative access routes to their properties.
The eastbound A41, and lane one of its westbound carriageway, will be shut from 8pm to 5am on Tuesday.
An advance notification of the closure says: “The works will involve resurfacing the worn-out carriageway.”
Workers will also replace road markings and studs and conduct minor drainage repairs during the closure.
They will reinstall counter loops beneath the A41 to monitor how much traffic is on it. This information will be used to help Herts County Council draw up its road safety policy.
Ice monitor detection devices will also be reinstalled there, so that the council can monitor the road’s temperature and know when to send the gritters there.
The advance notification warns that bus services may also be disrupted and says further details can be found at www.intalink.org.uk
The notice says: “Some degree of disruption and delay can be expected as a result of the works.
“While we will make every effort to minimise this, please allow extra time for any journeys you make while the works are in progress. We greatly appreciate your patience and co-operation.”
Roads bosses came under fire earlier this year when Les Miserables production designer Eve Stewart, who lives in Kitsbury Road, Berkhamsted, said the state of the A41 was ‘disgusting’.
The 51-year-old, who has since won a Bafta for her work on the film, said it made her afraid to bring film-makers into Herts.